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Associate Director , Drug Discovery /Formulation

  • Beacon Hill Staffing Group - Pharma
  • 02/14/20
  • Boston, MA
  • 02108
  • Full-Time
Develop nanoparticle, targeted nanoparticle, and conjugate based formulations for the in vivo delivery of Cas9 mRNA and sgRNA with activity and safety profiles suitable for clinical development.
As required, develop new formulation processes for encapsulation of CRISPR/cas9 components. Establish and develop advanced analytical techniques to build a mechanistic understanding of newly developed formulations.
Lead, train and mentor a group of scientists and research associates in formulation.
Collaborate closely with R&D groups in Biology, RNA, Chemistry, and Pharmacology to evaluate the efficacy and safety of formulations.
Provide scientific expertise and guidance in supporting the formulation/delivery needs across the organization.
Develop intellectual property, publish scientific papers and other tasks related to the Companys scientific and business interests.
Keep up-to-date with new developments in the formulation and delivery field.
Expertise with a broad spectrum of formulation processes and analytical techniques applicable to non-viral delivery systems for nucleic acids. Preferably has prior experience with lipid nanoparticle (LNP) formulations for nucleic acids.
Strong understanding of nanoparticle formulation and complexity of biological interactions for successful in vivo delivery.
Demonstrated creativity and problem-solving skills.
Ability to manage a group within a broader collaborative cross-functional team.
Organized, detail-oriented, and a self-starter who continuously seeks to improve existing laboratory methods and processes.
Effective verbal and written communication skills, including ability to develop project plans and interact with senior management.
Ph.D. in Engineering, Chemistry or Pharmaceutical Sciences or related discipline with at least 7 years of post-PhD experience and at least 4 years of supervisory experience in an industrial setting.
Proven track record of innovation and development of nanoparticle formulations.

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