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Bioinformatics and Computational Scientist

  • Beacon Hill Staffing Group - Pharma
  • 10/08/19
  • Newtonville, MA
  • 02460
  • Full-Time

Development and utilization of computational tools for clinical data analysis and data mining to identify factors (e.g., genetic markers) that correlate with clinical response to drug candidates
Work as a member of cross-functional Response Working Group to develop response factor hypotheses and develop analysis plans to test the hypotheses
Establish processes for data manipulation & analysis
Evaluate potential commercially available analysis tools
Conduct analyses of operational data across all functions at Karyopharm to generate quantitative assessments of operational performance. Examples include analysis of clinical site performance data and evaluation of time to key operational milestones such as contract execution, site activation, database lock or regulatory approval.


Master Degree or Ph.D. in bioinformatics, computational biology, biochemistry, biological sciences or related field with at least 3 years of experience working in drug development/bioinformatics.
Proficient in the identification, download, manage, and analysis of high-dimensional data sets
Experience with analysis of mRNA expression from various platforms such as Fluidigm, CyTOF, high throughput PCR, NanoString, and RNAseq
Experience with MATLAB, R, or Python and/or relational databases such as Oracle, SQL Server or MySQL
Experience with genomics data analysis required such as PLINK, Samtools, GATK, ANNOVAR, Tophat, STAR, Bioconductor
Familiarity with the UNIX and cluster computing environment such as Amazon Web Services preferred.
At least 3 years experience in drug development.
Good written and verbal communication skills

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